Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Fix: GPR curation for Glycosphingolipid metabolism #950

Merged
merged 3 commits into from
Jan 13, 2025

Conversation

JHL-452b
Copy link
Collaborator

@JHL-452b JHL-452b commented Dec 29, 2024

Main improvements in this PR:

As proposed in #893 #894 #895 :

  • Remove ENSG00000174684 from MAR00889;
  • Remove ENSG00000102595, ENSG00000134910, ENSG00000163527, ENSG00000119227, ENSG00000177191, ENSG00000069943, ENSG00000175711, ENSG00000139044, ENSG00000156966, ENSG00000060642, ENSG00000162885, ENSG00000172461, ENSG00000176383, ENSG00000147162, ENSG00000136731, ENSG00000180549, ENSG00000085998, ENSG00000143315, ENSG00000198488, ENSG00000170340, ENSG00000109586, ENSG00000179913, ENSG00000172728, ENSG00000176597, ENSG00000196371, ENSG00000182272 from MAR00924;
  • Remove ENSG00000134910, ENSG00000069943, ENSG00000162885, ENSG00000176383, ENSG00000136731, ENSG00000180549, ENSG00000167889, ENSG00000175711, ENSG00000172461, ENSG00000177191, ENSG00000170340, ENSG00000139044, ENSG00000060642, ENSG00000179913, ENSG00000187676, ENSG00000147162, ENSG00000176597, ENSG00000143315, ENSG00000198488, ENSG00000102595 from MAR00925;
  • Remove ENSG00000102595, ENSG00000134910, ENSG00000163527, ENSG00000119227, ENSG00000109586, ENSG00000139044, ENSG00000156966, ENSG00000060642, ENSG00000187676, ENSG00000162885, ENSG00000176383, ENSG00000136731, ENSG00000172728, ENSG00000180549, ENSG00000085998, ENSG00000198488, ENSG00000167889, ENSG00000170340, ENSG00000175711, ENSG00000143315, ENSG00000069943, ENSG00000147162, ENSG00000176597, ENSG00000177191 from MAR00926;
  • Remove ENSG00000138641 from MAR08379;
  • Remove ENSG00000138641 from MAR07185;
  • Remove ENSG00000156413 from MAR00873.

I hereby confirm that I have:

  • Tested my code on my own computer for running the model
  • Selected develop as a target branch
  • Any removed reactions and metabolites have been moved to the corresponding deprecated identifier lists

Copy link

This PR has been automatically tested with GH Actions. Here is the output of the MACAW test:

Starting dead-end test...
- Found 1523 dead-end metabolites.
- Found 1328 reactions incapable of sustaining steady-state fluxes in either direction due to these dead-ends.
- Found 1975 reversible reactions that can only carry steady-state fluxes in a single direction due to dead-ends.
Starting duplicate test...
- Skipping redox duplicates because no redox_pairs and/or proton_ids were provided.
- Found 447 reactions that were some type of duplicate:
- 0 were completely identical to at least one other reaction.
- 13 involve the same metabolites but go in the opposite direction or have the opposite reversibility as at least one other reaction.
- 447 involve the same metabolites but with different coefficients as at least one other reaction.

This and a more detailed output from MACAW are also committed to data/macawResults/.

Note: In the case of multiple test runs, this post will be edited.

Copy link
Collaborator

@hhl-24 hhl-24 left a comment

Choose a reason for hiding this comment

The reason will be displayed to describe this comment to others. Learn more.

LGTM!

Copy link

This PR has been automatically tested with GH Actions. Here is the output of the gene essentiality test:

     cellLine     TP     TN     FP     FN     accuracy    sensitivity    specificity       F1         MCC   
__________ __ ____ ___ ___ ________ ___________ ___________ ________ ________

{'DLD1' } 50 2141 84 270 0.8609 0.15625 0.96225 0.22026 0.17591
{'GBM' } 57 2132 77 278 0.86046 0.17015 0.96514 0.24307 0.2048
{'HCT116'} 71 2173 69 287 0.86308 0.19832 0.96922 0.28514 0.25578
{'HELA' } 35 2213 105 249 0.86395 0.12324 0.9547 0.16509 0.10772
{'RPE1' } 21 2156 113 254 0.85574 0.076364 0.9502 0.10269 0.036922
{'all' } 8 2350 132 112 0.90623 0.066667 0.94682 0.061538 0.012534

Note: In the case of multiple test runs, this post will be edited.

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
None yet
Projects
None yet
Development

Successfully merging this pull request may close these issues.

3 participants