Sookmyung Women's University Center for advanced Bioinformatic&Systems medicine Intern
- Image Normalization(Plate9)
- NC avg
- NC med
- NC sd
- Classify STK11 mutation cell line and wildtype cell line(in Lung(LUAD) NSCLC)
Lung → NSCLC,(SCLC,OTHER) → Check STK11 mutation
4 Types of cell lines
- LUNG NSCLC STK11 mutant
- LUNG NSCLC STK11 wild type
- LUNG Others
- Others
Calculate fold change t-test(pvalue) 1,2 / 1,3 / 1,4
Organize CCLE
shRNA : DRIVE
sgRNA : Depmap.org
CCLE COSMIC annotation : cell line(1267) - Major gene mutation information
DRIVE(shRNA) : cell line(398) gene(7726)
gene effect(sgRNA) : cell line(517) gene(16383)