Skip to content

data driven cutoffs

Jump to bottom
Brent Pedersen edited this page Jan 9, 2020 · 5 revisions

slivar ddc is used to find which cutoffs can be used to filter a VCF. It allows looking at individual FILTER fields and at INFO and FORMAT fields. It uses transmitted variants and mendelian violations in trios as a proxy for true and false positives: a good filter will retain most transmitted variants and remove many violations.

The give below shows usage:

Clone this wiki locally