CanIsoNet

We have recently analyzed the pathogenic impact of isoform switching events in 1209 cancer samples covering 27 different cancer types. Expanding on those results, we have built a user-friendly Cancer Isoform Specific Interaction Network (CanIsoNet) database to make our results more accessible to the cancer research community. CanIsoNet is the first webserver that merges isoform switching events in different cancer types with their functional impact level and showing them on STRING interaction network. It holds annotations for 7144 genes, 11,041 isoforms and 31,748 unique isoform switching events across 24 cancer types. CanIsoNet provides two main functionalities to the users: 1) Browsing various statistics on cancer-specific isoform switching events in each cancer samples from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project. 2) Exploring and visualizing network disruptions in the STRING interaction network.

Availability

CanIsoNet is freely available at caniso.net

Citation

If you use CanIsoNet v1.0, please cite the following articles:

Kahraman et al., Pathogenic impact of transcript isoform switching in 1,209 cancer samples covering 27 cancer types using an isoform-specific interaction network Scientific Reports, 2020.

Karakulak et al., CanIsoNet: A Database to Study the Functional Impact of Isoform Switching Events in Cancer, BioRxiv, 2021

Contact Us

[email protected]

Shield:

This work is licensed under a Creative Commons Attribution 4.0 International License.