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Merge pull request #59 from cov-lineages/dev
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adding in BA.4 and BA.5 constellations
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aineniamh authored Apr 12, 2022
2 parents 9e2d67f + 586a235 commit 34d87fb
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Showing 7 changed files with 159 additions and 22 deletions.
2 changes: 1 addition & 1 deletion constellations/__init__.py
Original file line number Diff line number Diff line change
@@ -1,3 +1,3 @@
_program = "constellations"
__version__ = "v0.1.4"
__version__ = "v0.1.5"

5 changes: 1 addition & 4 deletions constellations/definitions/cB.1.1.529.json
Original file line number Diff line number Diff line change
Expand Up @@ -22,7 +22,6 @@
"nuc:C3037T",
"orf1ab:T3255I",
"orf1ab:P3395H",
"orf1ab:SGF3675-",
"orf1ab:P4715L",
"orf1ab:I5967V",
"spike:G142D",
Expand All @@ -34,7 +33,6 @@
"spike:S477N",
"spike:T478K",
"spike:E484A",
"spike:Q493R",
"spike:Q498R",
"spike:N501Y",
"spike:Y505H",
Expand All @@ -53,8 +51,7 @@
"nuc:C27807T",
"nuc:A28271T",
"n:P13L",
"del:28362:9",
"n:RG203KR"
"del:28362:9"
],
"note": "Common mutations to the sublineages found",
"rules": {
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11 changes: 6 additions & 5 deletions constellations/definitions/cBA.1.json
Original file line number Diff line number Diff line change
Expand Up @@ -23,6 +23,7 @@
"del:6513:3",
"orf1ab:A2710T",
"orf1ab:L3674F",
"orf1ab:SGF3675-",
"orf1ab:I3758V",
"nuc:T13195C",
"nuc:C15240T",
Expand All @@ -34,26 +35,26 @@
"nuc:22205+GAGCCAGAA",
"spike:S371L",
"spike:G446S",
"spike:Q493R",
"spike:G496S",
"spike:T547K",
"spike:N856K",
"spike:L981F",
"nuc:C25000T",
"nuc:C25584T",
"m:D3G"
"m:D3G",
"n:RG203KR"
],
"note": "Unique mutations for sublineage",
"note2": "Requires ancestral mutation so scorpio tie breaks correctly",
"rules": {
"default": {
"min_alt": 14,
"max_ref": 3,
"nuc:T5386G": "not ref"
"max_ref": 3
},
"Probable": {
"min_alt": 10,
"max_ref": 8,
"nuc:T5386G": "not ref"
"max_ref": 8
}
}
}
16 changes: 10 additions & 6 deletions constellations/definitions/cBA.2.json
Original file line number Diff line number Diff line change
Expand Up @@ -26,6 +26,7 @@
"nuc:A9424G",
"orf1ab:T3090I",
"orf1ab:L3201F",
"orf1ab:SGF3675-",
"nuc:C10198T",
"nuc:G10447A",
"nuc:C15714T",
Expand All @@ -41,24 +42,27 @@
"spike:T376A",
"spike:D405N",
"spike:R408S",
"spike:Q493R",
"nuc:C25000T",
"nuc:C25584T",
"nuc:C26060T",
"nuc:C26858T",
"orf6:D61L",
"n:S413R"
"n:RG203KR",
"n:S413R"
],
"note": "Unique mutations for sublineage",
"rules": {
"default": {
"min_alt": 18,
"min_alt": 28,
"max_ref": 3,
"orf1ab:R5716C": "not ref"
"spike:Q493":"alt",
"n:P151":"ref",
"nuc:G27788":"ref"
},
"Probable": {
"min_alt": 12,
"max_ref": 8,
"orf1ab:R5716C": "not ref"
"min_alt": 20,
"max_ref": 8
}
}
}
11 changes: 5 additions & 6 deletions constellations/definitions/cBA.3.json
Original file line number Diff line number Diff line change
Expand Up @@ -22,12 +22,14 @@
"nuc:C832T",
"orf1ab:G1307S",
"orf1ab:T3090I",
"orf1ab:SGF3675-",
"nuc:G10447A",
"nuc:C11235T",
"nuc:C12880T",
"nuc:C15714T",
"orf1ab:I5967V",
"spike:A67V",
"spike:Q493R",
"del:21765:6",
"del:21987:9",
"del:22194:3",
Expand All @@ -36,21 +38,18 @@
"spike:G446S",
"orf3a:T223V",
"nuc:C26858T",
"n:RG203KR",
"n:S413R"
],
"note": "Unique mutations for sublineage",
"rules": {
"default": {
"min_alt": 11,
"max_ref": 3,
"nuc:C832T": "not ref",
"nuc:C11235T": "not ref"
"max_ref": 3
},
"Probable": {
"min_alt": 6,
"max_ref": 8,
"nuc:C832T": "not ref",
"nuc:C11235T": "not ref"
"max_ref": 8
}
}
}
69 changes: 69 additions & 0 deletions constellations/definitions/cBA.4.json
Original file line number Diff line number Diff line change
@@ -0,0 +1,69 @@
{
"label": "Omicron (BA.4-like)",
"description": "BA.4 lineage defining mutations",
"sources": [
],
"type": "variant",
"variant": {
"Pango_lineages": [
"BA.4"
],
"WHO_label": "Omicron",
"mrca_lineage": "BA.4",
"lineage_name": "BA.4",
"parent_lineage": "B.1.1.529",
"representative_genome": ""
},
"tags": [
"BA.4"
],
"sites": [
"orf1ab:S135R",
"orf1ab:T842I",
"orf1ab:G1307S",
"nuc:C4321T",
"orf1ab:T3090I",
"nuc:C10198T",
"nuc:G10447A",
"del:11288:9",
"nuc:G12160A",
"nuc:C12880T",
"nuc:C15714T",
"orf1ab:R5716C",
"orf1ab:T6564I",
"nuc:A20055G",
"spike:T19I",
"s:HV69-",
"nuc:T22200G",
"spike:V213G",
"spike:S371F",
"spike:T376A",
"spike:D405N",
"spike:L452R",
"spike:F486V",
"nuc:C25000T",
"nuc:C25584T",
"nuc:C26060T",
"nuc:C26858T",
"orf6:D61L",
"nuc:G27788T",
"n:P151S",
"n:RG203KR",
"n:S413R"
],
"note": "Unique mutations for sublineage",
"rules": {
"default": {
"min_alt": 30,
"max_ref": 5,
"m:D3N":"ref",
"s:Q493":"ref",
"orf6:D61":"not ref",
"n:P151S":"alt"
},
"Probable": {
"min_alt": 20,
"max_ref": 8
}
}
}
67 changes: 67 additions & 0 deletions constellations/definitions/cBA.5.json
Original file line number Diff line number Diff line change
@@ -0,0 +1,67 @@
{
"label": "Omicron (BA.5-like)",
"description": "BA.5 lineage defining mutations",
"sources": [
],
"type": "variant",
"variant": {
"Pango_lineages": [
"BA.5"
],
"WHO_label": "Omicron",
"mrca_lineage": "BA.5",
"lineage_name": "BA.5",
"parent_lineage": "B.1.1.529",
"representative_genome": ""
},
"tags": [
"BA.5"
],
"sites": [
"orf1ab:S135R",
"orf1ab:T842I",
"orf1ab:G1307S",
"nuc:C4321T",
"orf1ab:T3090I",
"nuc:C10198T",
"nuc:G10447A",
"del:11288:9",
"nuc:G12160A",
"nuc:C12880T",
"nuc:C15714T",
"orf1ab:R5716C",
"orf1ab:T6564I",
"nuc:A20055G",
"spike:T19I",
"s:HV69-",
"nuc:T22200G",
"spike:V213G",
"spike:S371F",
"spike:T376A",
"spike:D405N",
"spike:L452R",
"spike:F486V",
"nuc:C25000T",
"nuc:C25584T",
"nuc:C26060T",
"m:D3N",
"n:RG203KR",
"n:S413R"
],
"note": "Unique mutations for sublineage",
"rules": {
"default": {
"min_alt": 28,
"max_ref": 5,
"s:Q493":"ref",
"nuc:C26858":"ref",
"nuc:G27788":"ref",
"n:P151":"ref",
"m:D3":"alt"
},
"Probable": {
"min_alt": 20,
"max_ref": 8
}
}
}

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