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Merge pull request #66 from cov-lineages/add_xbb
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Add xbb
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rmcolq authored Jun 7, 2023
2 parents 61e2a6b + 65101be commit 826f0f4
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Showing 10 changed files with 201 additions and 14 deletions.
3 changes: 1 addition & 2 deletions constellations/definitions/cB.1.1.529.json
Original file line number Diff line number Diff line change
Expand Up @@ -28,7 +28,6 @@
"spike:G339D",
"spike:S373P",
"spike:S375F",
"spike:K417N",
"spike:N440K",
"spike:S477N",
"spike:T478K",
Expand Down Expand Up @@ -57,7 +56,7 @@
"rules": {
"default": {
"min_alt": 22,
"max_ref": 2,
"max_ref": 3,
"spike:D614G": "not ref"
},
"Probable": {
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14 changes: 5 additions & 9 deletions constellations/definitions/cBA.2.json
Original file line number Diff line number Diff line change
Expand Up @@ -21,7 +21,7 @@
],
"sites": [
"orf1ab:S135R",
"orf1ab:T842I",
"orf1ab:T842I",
"orf1ab:G1307S",
"nuc:C4321T",
"orf1ab:L3027F",
Expand All @@ -38,15 +38,14 @@
"nuc:A20055G",
"spike:T19I",
"del:21633:9",
"nuc:T22200G",
"spike:V213G",
"spike:S371F",
"spike:T376A",
"spike:D405N",
"spike:R408S",
"spike:Q493R",
"orf3a:T223I",
"nuc:C25000T",
"nuc:C25584T",
"nuc:C26060T",
"nuc:C26858T",
"orf6:D61L",
"n:RG203KR",
Expand All @@ -55,11 +54,8 @@
"note": "Unique mutations for sublineage",
"rules": {
"default": {
"min_alt": 27,
"max_ref": 3,
"spike:Q493":"alt",
"n:P151":"ref",
"nuc:G27788":"ref"
"min_alt": 23,
"max_ref": 4
}
}
}
4 changes: 2 additions & 2 deletions constellations/definitions/cBA.5.json
Original file line number Diff line number Diff line change
Expand Up @@ -52,8 +52,8 @@
"note": "Unique mutations for sublineage",
"rules": {
"default": {
"min_alt": 27,
"max_ref": 5,
"min_alt": 25,
"max_ref": 4,
"s:Q493":"ref",
"nuc:C26858":"ref",
"nuc:G27788":"ref",
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31 changes: 31 additions & 0 deletions constellations/definitions/cXBB-parent1.json
Original file line number Diff line number Diff line change
@@ -0,0 +1,31 @@
{
"label": "XBB-parent1",
"description": "Majority parent of XBB recombinant lineage",
"sources": [
],
"type": "variant",
"variant": {
"mrca_lineage": "",
"lineage_name": "XBB-parent1",
"parent_lineage": "BA.2",
"representative_genome": ""
},
"tags": [
"XBB"
],
"note": "Shared mutations with BA.2.75 parent",
"note": "Likely breakpoint: ~ S:446",
"sites": [
"spike:G339H",
"spike:G446S",
"spike:N460K",
"e:T11A",
"nuc:C25416T"
],
"rules": {
"default": {
"min_alt": 2,
"max_ref": 2
}
}
}
27 changes: 27 additions & 0 deletions constellations/definitions/cXBB-parent2.json
Original file line number Diff line number Diff line change
@@ -0,0 +1,27 @@
{
"label": "XBB-parent2",
"description": "Minority parent of XBB recombinant lineage",
"sources": [
],
"type": "variant",
"variant": {
"mrca_lineage": "",
"lineage_name": "XBB-parent2",
"parent_lineage": "XBB-parent1",
"representative_genome": ""
},
"tags": [
"XBB"
],
"note": "Shared mutations with BA.2.10.1 parent",
"note": "Likely breakpoint: ~ S:446",
"sites": [
"orf1b:S959P"
],
"rules": {
"default": {
"min_alt": 0,
"max_ref": 1
}
}
}
32 changes: 32 additions & 0 deletions constellations/definitions/cXBB.1.16.json
Original file line number Diff line number Diff line change
@@ -0,0 +1,32 @@
{
"label": "Omicron (XBB.1.16-like)",
"description": "XBB.1.16 lineage defining mutations",
"sources": [
],
"type": "variant",
"variant": {
"Pango_lineages": [
"XBB.1.16"
],
"WHO_label": "Omicron",
"parent_lineage": "XBB.1",
"mrca_lineage": "XBB.1.16",
"lineage_name": "XBB.1.16",
"representative_genome": ""
},
"tags": [
"XBB.1.16"
],
"note": "Unique mutations for XBB.1.16 sublineage",
"sites": [
"orf1b:D1746Y",
"spike:E180V",
"nuc:T28297C",
"nuc:A28447G",
"nuc:C29386T"
],
"rules": {
"min_alt": 3,
"max_ref": 1
}
}
31 changes: 31 additions & 0 deletions constellations/definitions/cXBB.1.5.json
Original file line number Diff line number Diff line change
@@ -0,0 +1,31 @@
{
"label": "Omicron (XBB.1.5-like)",
"description": "XBB.1.5 lineage defining mutations",
"sources": [
],
"type": "variant",
"variant": {
"Pango_lineages": [
"XBB.1.5"
],
"WHO_label": "Omicron",
"parent_lineage": "XBB.1",
"mrca_lineage": "XBB.1.5",
"lineage_name": "XBB.1.5",
"representative_genome": ""
},
"tags": [
"XBB.1.5"
],
"note": "Unique mutations for XBB.1.5 sublineage",
"sites": [
"nuc:T17124C",
"spike:G252V",
"spike:F486P"
],
"rules": {
"min_alt": 2,
"max_ref": 0,
"spike:F486":"alt"
}
}
30 changes: 30 additions & 0 deletions constellations/definitions/cXBB.1.json
Original file line number Diff line number Diff line change
@@ -0,0 +1,30 @@
{
"label": "Omicron (XBB.1-like)",
"description": "XBB.1 lineage defining mutations",
"sources": [
],
"type": "variant",
"variant": {
"Pango_lineages": [
"XBB.1"
],
"WHO_label": "Omicron",
"parent_lineage": "XBB",
"mrca_lineage": "XBB.1",
"lineage_name": "XBB.1",
"representative_genome": ""
},
"tags": [
"XBB.1"
],
"note": "Unique mutations for XBB.1 sublineage",
"sites": [
"spike:R408S",
"spike:K417N",
"orf8:G8*"
],
"rules": {
"min_alt": 2,
"max_ref": 0
}
}
41 changes: 41 additions & 0 deletions constellations/definitions/cXBB.json
Original file line number Diff line number Diff line change
@@ -0,0 +1,41 @@
{
"label": "Omicron (XBB-like)",
"description": "XBB recombinant lineage defining mutations",
"sources": [
],
"type": "variant",
"variant": {
"Pango_lineages": [
"XBB"
],
"WHO_label": "Omicron",
"parent_lineage": "XBB-parent2",
"mrca_lineage": "XBB",
"lineage_name": "XBB",
"representative_genome": ""
},
"tags": [
"XBB"
],
"note": "Unique mutations for XBB sublineage",
"sites": [
"spike:V83A",
"spike:Y144-",
"spike:H146Q",
"spike:Q183E",
"spike:V213E",
"spike:R346T",
"spike:L368I",
"spike:V445P",
"spike:F486S",
"spike:F490S",

"nuc:C15738T",
"nuc:T15939C",
"nuc:T17859C"
],
"rules": {
"min_alt": 5,
"max_ref": 3
}
}
2 changes: 1 addition & 1 deletion constellations/definitions/cXE.json
Original file line number Diff line number Diff line change
Expand Up @@ -30,7 +30,7 @@
"nuc:C14599T"
],
"rules": {
"min_alt": 2,
"min_alt": 3,
"max_ref": 0
}
}

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