Merge pull request #29085 from geneontology/issue-25274

NTR GO:0170060, microtubule destablizing activity; Fixes #25274
geneontology · Oct 21, 2024 · 8e9beef · 8e9beef
2 parents 2c927c8 + 0c81186
commit 8e9beef
Showing 1 changed file with 15 additions and 1 deletion.
diff --git a/src/ontology/go-edit.obo b/src/ontology/go-edit.obo
@@ -80526,7 +80526,7 @@ xref: EC:5.6.1.1
 xref: MetaCyc:3.6.4.3-RXN
 is_a: GO:0140096 ! catalytic activity, acting on a protein
 is_a: GO:0140657 ! ATP-dependent activity
-is_a: GO:0140776 ! protein-containing complex destabilizing activity
+is_a: GO:0170060 ! microtubule destablizing activity
 relationship: part_of GO:0000226 ! microtubule cytoskeleton organization
 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/23065" xsd:anyURI
 
@@ -467307,6 +467307,20 @@ property_value: term_tracker_item "https://github.com/geneontology/go-ontology/i
 created_by: ew
 creation_date: 2024-03-26T23:34:04Z
 
+[Term]
+id: GO:0170060
+name: microtubule destablizing activity
+namespace: molecular_function
+def: "A protein-containing complex destabilizing activity that promotes microtubule catastrophe (transition from microtubule growth to microtubule shrinkage)." [PMID:29858272, PMID:36435910]
+synonym: "microtubule catastrophe inducing activity" BROAD []
+synonym: "microtubule catastrophe promoting activity" BROAD []
+is_a: GO:0140776 ! protein-containing complex destabilizing activity
+intersection_of: GO:0140776 ! protein-containing complex destabilizing activity
+intersection_of: results_in GO:0007019 ! microtubule depolymerization
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25274" xsd:anyURI
+created_by: ew
+creation_date: 2024-10-21T18:05:48Z
+
 [Term]
 id: GO:0180000
 name: histone methyltransferase inhibitor activity