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Term name and definition update: collagen sheet (GO:0098646) to interstitial hexagonal collagen network #29415
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collagen type X trimer (GO:0005599) is already part_of collagen sheet (GO:0098646), is this OK ? (I dont think it should be is_a? ) |
Hi @DaiqingChen I dont see COL8A1(UniProtKB:P27658, 9606 Homo sapiens annotated to collagen sheet (GO:0098646); which annotation do you want to change? Thanks, Pascale |
Term now looks like this:
|
Yes, collagen type X trimer(GO:0005599) should be part_of collagen sheet(GO:0098646). |
Hi Pascale, Best, |
Yes, while we would like to obsolete term "sheet-forming collagen trimer(GO:0030935)", #29416 |
Hi @pgaudet , |
Thanks @DaiqingChen Thanks, Pascale |
GO term ID and label for which you request a definition update
collagen sheet (GO:0098646)
Note: "collagen sheet" is NOT synonyms of interstitial hexagonal collagen network, requesting "definition update" instead of obsoleting and adding new term because the annotations are the same(collagen type X trimer).
New proposed definition (genus-differentia pattern, plus additional information if needed)
Reference(s)
collagen type X trimers forms Hexagonal supramolecular structure: PMID: 21421911
collagen type X trimers occurs in interstitial matrix: PMID: 34948124
Parent term(s)
Children terms (if applicable)
collagen type X trimer (GO:0005599)
Remove gene product
The network-forming collagen forms two types of supramolecular structures(chicken-wire and hexagonal), the hexagonal collagen network is formed by collagen type VIII trimers in the basement membrane and collagen type X trimers in the interstitial matrix.
However, the collagen type X trimer is not in the same area of interstitial matrix that composed of collagen types I, III, and V, but specifically localized to the cartilage matrix that's closer to the chondrocytes.
Frame work in slide page 1 for localization information, slide page 3 for supramolecular complex information, and slide page 7 for the overview of relationships.https://docs.google.com/presentation/d/1zxL0gt5vOynmJsS8BP-Xqs_0sTaEB8Zo/edit?usp=sharing&ouid=109267399050361021326&rtpof=true&sd=true
Screen shot of slide page 7, interstitial hexagonal collagen network is pointed with arrows
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