IIIandMe: An Algorithm for Chromosome-scale Haplotype Determination Using Genome-wide Variants of Three Haploid Reproductive Cells
Our recent algorithm, Hapi, infers chromosome-scale haplotypes using genomic data of a small number of single gametes. Its advanced version, IIIandMe, is proposed here to achieve comparable phasing accuracy as few as three gametes, pushing the analysis to its limit. he new method is validated with simulation and a citrus gamete dataset. The rapid advancement in genotyping technologies promises a broad application of IIIandMe in disclosing important genetic information.
### Install dependencies ahead
install.packages('devtools')
devtools::install_github('Jialab-UCR/IIIandMe')
The manual of IIIandMe: IIIandMe manual