MuSiC is a deconvolution method that utilizes cross-subject scRNA-seq to estimate cell type proportions in bulk RNA-seq data.
Please cite the following publication:
Bulk tissue cell type deconvolution with multi-subject single-cell expression reference
X. Wang, J. Park, K. Susztak, N.R. Zhang, M. Li
Nature Communications. 2019 Jan 22 https://doi.org/10.1038/s41467-018-08023-x
# install devtools if necessary
install.packages('devtools')
# install the MuSiC package
devtools::install_github('xuranw/MuSiC')
# load
library(MuSiC)Please see Tutorial.