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Optimal sequence-to-graph alignment with recombinations using wavefront algorithm.

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iFoxz17/WF_Recgraph

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WF_RecGraph

WF_Recgraph contains an optimizazion of RecGraph for variation graph to sequence alignment, implementing an a multithreading approach based on the wavefront algorithm.

Optimizated complexity

  • $T(n, m, \overline{d}, p) = O(\min{(n, m)} \cdot \overline{d} \cdot p)$
  • $M(n, m, \overline{d}, p) = O(\max{(n, m)} \cdot \overline{d} \cdot p)$

Future improvements

  • Extend weighted edit distance to gap pairwise alignment;
  • Reduce memory complexity of wf_vec implementation to $O(\overline{d}^2 \cdot p)$;
  • Implements wavefront heuristics.

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Optimal sequence-to-graph alignment with recombinations using wavefront algorithm.

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