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Kozo Nishida edited this page Oct 8, 2020 · 1 revision

Full support for KEGG Pathway Database

Now KEGGScape supports all pathway data available in KGML format, including:

  • Metabolic Pathways
  • Global Map for Metabolic Pathways
  • Overview Maps
  • Signaling Pathways
  • Organismal Systems
  • Human Disease Pathways

Better Visual Styles

We have tweaked custom Visual Style to present as mush information as possible out of the original KGML files. Directionality and type of reactions/relations are mapped to human understandable visual properties.

Maplink Expansion from Context Menu

KEGG pathways have maplink nodes which point to other pathways. Cytoscape can automatically import those pathways by selecting a context menu:

  • Select a maplink node and right-click to expand!

  • Actual pathway data will be fetched dynamically from KEGG pathway database.

View Details in Web Browser

If you need complete information about compounds, genes, or pathways, you can view details in web browser by selecting right-click menu item.

Network Colleciton Support

From this version, KEGGScape supports network collection. You can organize your pathways based on the biological context.

Import Extra Annotations from KEGG

By checking options in import window, you can add extra information from KEGG:

  • KEGG Modules
  • Diseases
  • Pathway classes

Group Support

Group information in KGML is now mapped to Cytoscape's CyGroup. This means intrnally, grouped nodes are handled as CyGroup, instead of set of nodes.

  • Default representation (set of individdual nodes):

  • Collapsed to a single group node:

Bug Fixes

Lots of bugs are fixed. Some of the missed edges in the last version are now correctly mapped in the view.


Future Plan

TODO

  • Advanced example workflow written with cy-rest and IPython Notebook
  • Automatic import from list of pathway IDs
  • Import additional annotation on-demand:
    • KEGG Modules
    • Drug targets
    • etc.
  • Expanding pathways in existing network view