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andrej-fischer committed Apr 4, 2014
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8 changes: 8 additions & 0 deletions changelog.md
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# changelog for cloneHD/filterHD

## v1.17.3 / to come

* new program `pre-filter`
* `--snv-pen` to `--snv-pen-high` and `--snv-pen-mult`
* `--baf-pen` to `--baf-pen-compl`
* `--cna-pen` to `--cna-pen-zero`, `--cna-pen-diff` and `cna-pen-norm`
* split README

## v1.17.2 / 27.03.2014

* new output: posterior per subclone, goodness of fit (GOF) per
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4 changes: 2 additions & 2 deletions docs/README-pre-filter.md
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Expand Up @@ -16,11 +16,11 @@ The program `pre-filter` can be used to remove loci based on the observed read d

The windowed tracks are used for pre-filtering. They are printed for all loci to a file named `pre.track.txt`. Use this to inspect and tune the pre-filter thresholds.

* `pick-from [file]` Pre-filter data in this file by picking loci present in `match-to`.
* `--pick-from [file]` Pre-filter data in this file by picking loci present in `match-to`.

Only loci are selected which fall into a bin also present in `match-to`. If bins in `match-to` are in kb (1000, 2000 etc., i.e. 1-1000, 1001-2000 etc.) then loci in `pick-from` are rounded to the next 1000 above.

* `match-to [file]` Use this file as reference to pick loci in `pick-from`.
* `--match-to [file]` Use this file as reference to pick loci in `pick-from`.

Loci in this file are assumed to be equidistant (e.g. per 1 kb, not all bins need be present). The bin width is decided automatically by majority.

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