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kkmann authored Jul 2, 2019
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# adoptr <a href='https://github.com/kkmann/adoptr'><img src='man/figures/logo.png' align="right" height="139" /></a>


Adaptive optimal two-stage designs for clinical trials with one or two arms.
Adaptive optimal two-stage designs for clinical trials with one or two arms for details on the core theoretical background, see:

Pilz M, Kunzmann K, Herrmann C, Rauch G, Kieser M. A variational approach to
optimal two-stage designs. Statistics in Medicine. 2019;1–13.
https://doi.org/10.1002/sim.8291



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using the **bookdown** package.
The sources are available at https://github.com/kkmann/adoptr-validation-report and
the last build version is hosted at https://kkmann.github.io/adoptr-validation-report.



## Reference

Pilz M, Kunzmann K, Herrmann C, Rauch G, Kieser M. A variational approach to
optimal two-stage designs. Statistics in Medicine. 2019;1–13.
https://doi.org/10.1002/sim.8291

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