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<!DOCTYPE html>
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<h1><span class="grey">Optical</span> Neurophysiology of Behavior</h1>
<p>
Our lab seeks to understand how neural circuits encode complex behavior. In particular, we study the model organism <i>C. elegans</i>, a microscopic worm with a simple nervous system capable of rich behaviors. We have pioneered optogenetic microscopy techniques to optically manipulate and monitor neural activity in worms as they move. <a class="" href="research.php">Read more »</a></p>
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<h3>Andrew Leifer</h3><h4 class="grey"><i>Principal Investigator</i></h4>
<p>My research combines techniques from neuroscience, physics, engineering and computer science to study the dynamics of neural circuits in awake moving organisms. We are located at the inter-disciplinary Lewis-Sigler Institute for Integrative genomics.
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<p>To study neurocircuits, we build tools that monitor and manipulate neural activity in a worm with light.</p>
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<p>Changes to the worm's behavior are precisely quantified.</p>
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<p>These tools provide functional information about how neurons work together in a circuit.</p>
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<p>The worm's neural activity is measured simultaneously with behavior.</p>
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<b class="project-name">The Leifer Lab</b> is now part of the <a href="http://www.princeton.edu/neuroscience/" target="_blank">Princeton Neuroscience Institute</a>.
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<b class="name">DNA Origami Nanobarcode</b> paper was recently published in <a href="http://www.nature.com/nchem/journal/v4/n10/full/nchem.1451.html" target="_blank">Nature Chemistry</a> with Lin et al.
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<b class="name">Blue light</b>
<i class="icon-play"></i> causes the worm to experience the sensation of touch, and so it recoils. <a href="#">More video »</a>
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