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../neuron/apcount.mod |
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../neuron/exp2syn.mod |
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../neuron/expsyn.mod |
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../neuron/feature.mod |
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TITLE hh.mod squid sodium, potassium, and leak channels | ||
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||
COMMENT | ||
This is the original Hodgkin-Huxley treatment for the set of sodium, | ||
potassium, and leakage channels found in the squid giant axon membrane. | ||
("A quantitative description of membrane current and its application | ||
conduction and excitation in nerve" J.Physiol. (Lond.) 117:500-544 (1952).) | ||
Membrane voltage is in absolute mV and has been reversed in polarity | ||
from the original HH convention and shifted to reflect a resting potential | ||
of -65 mV. | ||
Remember to set a squid-appropriate temperature | ||
(e.g. in HOC: "celsius=6.3" or in Python: "h.celsius=6.3"). | ||
See squid.hoc for an example of a simulation using this model. | ||
SW Jaslove 6 March, 1992 | ||
ENDCOMMENT | ||
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UNITS { | ||
(mA) = (milliamp) | ||
(mV) = (millivolt) | ||
(S) = (siemens) | ||
} | ||
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? interface | ||
NEURON { | ||
SUFFIX hh | ||
REPRESENTS NCIT:C17145 : sodium channel | ||
REPRESENTS NCIT:C17008 : potassium channel | ||
USEION na READ ena WRITE ina REPRESENTS CHEBI:29101 | ||
USEION k READ ek WRITE ik REPRESENTS CHEBI:29103 | ||
NONSPECIFIC_CURRENT il | ||
RANGE gnabar, gkbar, gl, el, gna, gk | ||
RANGE minf, hinf, ninf, mtau, htau, ntau | ||
THREADSAFE : assigned GLOBALs will be per thread | ||
} | ||
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PARAMETER { | ||
gnabar = .12 (S/cm2) <0,1e9> | ||
gkbar = .036 (S/cm2) <0,1e9> | ||
gl = .0003 (S/cm2) <0,1e9> | ||
el = -54.3 (mV) | ||
} | ||
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STATE { | ||
m h n | ||
} | ||
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ASSIGNED { | ||
v (mV) | ||
celsius (degC) | ||
ena (mV) | ||
ek (mV) | ||
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gna (S/cm2) | ||
gk (S/cm2) | ||
ina (mA/cm2) | ||
ik (mA/cm2) | ||
il (mA/cm2) | ||
minf hinf ninf | ||
mtau (ms) htau (ms) ntau (ms) | ||
} | ||
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? currents | ||
BREAKPOINT { | ||
SOLVE states METHOD cnexp | ||
gna = gnabar*m*m*m*h | ||
ina = gna*(v - ena) | ||
gk = gkbar*n*n*n*n | ||
ik = gk*(v - ek) | ||
il = gl*(v - el) | ||
} | ||
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INITIAL { | ||
rates(v) | ||
m = minf | ||
h = hinf | ||
n = ninf | ||
} | ||
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? states | ||
DERIVATIVE states { | ||
rates(v) | ||
m' = (minf-m)/mtau | ||
h' = (hinf-h)/htau | ||
n' = (ninf-n)/ntau | ||
} | ||
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:LOCAL q10 | ||
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? rates | ||
PROCEDURE rates(v(mV)) { :Computes rate and other constants at current v. | ||
:Call once from HOC to initialize inf at resting v. | ||
LOCAL alpha, beta, sum, q10 | ||
: `TABLE minf` will be replaced with `:TABLE minf` if CoreNEURON enabled) | ||
TABLE minf, mtau, hinf, htau, ninf, ntau DEPEND celsius FROM -100 TO 100 WITH 200 | ||
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UNITSOFF | ||
q10 = 3^((celsius - 6.3)/10) | ||
:"m" sodium activation system | ||
alpha = .1 * vtrap(-(v+40),10) | ||
beta = 4 * exp(-(v+65)/18) | ||
sum = alpha + beta | ||
mtau = 1/(q10*sum) | ||
minf = alpha/sum | ||
:"h" sodium inactivation system | ||
alpha = .07 * exp(-(v+65)/20) | ||
beta = 1 / (exp(-(v+35)/10) + 1) | ||
sum = alpha + beta | ||
htau = 1/(q10*sum) | ||
hinf = alpha/sum | ||
:"n" potassium activation system | ||
alpha = .01*vtrap(-(v+55),10) | ||
beta = .125*exp(-(v+65)/80) | ||
sum = alpha + beta | ||
ntau = 1/(q10*sum) | ||
ninf = alpha/sum | ||
} | ||
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FUNCTION vtrap(x,y) { :Traps for 0 in denominator of rate eqns. | ||
if (fabs(x/y) < 1e-6) { | ||
vtrap = y*(1 - x/y/2) | ||
}else{ | ||
vtrap = x/(exp(x/y) - 1) | ||
} | ||
} | ||
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||
UNITSON |
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../neuron/intfire4.mod |
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../neuron/netstim.mod |
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../neuron/oclmp.mod |
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../neuron/passive.mod |
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../neuron/pattern.mod |
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../neuron/ppmark.mod |
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../neuron/stim.mod |
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../neuron/svclmp.mod |
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../neuron/syn.mod |
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../neuron/vclmp.mod |
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