Skip to content

Commit

Permalink
NTR-border-associated-macrophage-and-subclasses
Browse files Browse the repository at this point in the history 
Fixes #2285
  • Loading branch information
@AvolaAmg
AvolaAmg committed Mar 7, 2024
1 parent 2180772 commit 5457dfc
Showing 1 changed file with 66 additions and 11 deletions.
77 changes: 66 additions & 11 deletions src/ontology/cl-edit.owl
View file
Original file line number Diff line number Diff line change
Expand Up @@ -3023,6 +3023,10 @@ Declaration(Class(obo:CL_4040002))
Declaration(Class(obo:CL_4040003))
Declaration(Class(obo:CL_4040004))
Declaration(Class(obo:CL_4040005))
Declaration(Class(obo:CL_4042001))
Declaration(Class(obo:CL_4042002))
Declaration(Class(obo:CL_4042003))
Declaration(Class(obo:CL_4042004))
Declaration(Class(obo:CP_0000000))
Declaration(Class(obo:CP_0000025))
Declaration(Class(obo:CP_0000027))
Expand Down Expand Up @@ -11260,26 +11264,32 @@ SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000878 obo:CL_0000864

# Class: obo:CL_0000879 (meningeal macrophage)

AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:ana") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMID:11591794") obo:IAO_0000115 obo:CL_0000879 "A central nervous system macrophage found in the meninges (the three membranes that surround the brain). This macrophage types is highly phagocytic and expresses scavenger receptors.")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:ana") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMID:11591794") Annotation(oboInOwl:hasDbXref "PMID:24078900") Annotation(oboInOwl:hasDbXref "PMID:37232741") obo:IAO_0000115 obo:CL_0000879 "A central nervous system macrophage that is part of the meninges. This macrophage types is highly phagocytic, expresses scavenger receptors, has dynamic protrusions and extends its processes during inflammation. The cell body of this macrophage is elongated and amoeboid spindle-shaped with limited mobility.")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:33556248") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasExactSynonym obo:CL_0000879 "MM")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:38347231") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasExactSynonym obo:CL_0000879 "MnMΦ")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:33556248") oboInOwl:hasExactSynonym obo:CL_0000879 "subdural leptomeningeal macrophage")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:28323268") oboInOwl:hasExactSynonym obo:CL_0000879 "subdural meningeal macrophage")
AnnotationAssertion(rdfs:label obo:CL_0000879 "meningeal macrophage")
EquivalentClasses(obo:CL_0000879 ObjectIntersectionOf(obo:CL_0000878 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002360) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0005044)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000879 obo:CL_0000878)
EquivalentClasses(obo:CL_0000879 ObjectIntersectionOf(obo:CL_4042001 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002360) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0005044)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000879 obo:CL_4042001)

# Class: obo:CL_0000880 (choroid-plexus macrophage)
# Class: obo:CL_0000880 (choroid plexus macrophage)

AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:ana") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMID:9550136") obo:IAO_0000115 obo:CL_0000880 "A central nervous system macrophage found at the interface between the blood and the cerebrospinal fluid in the brain. This cell expresses scavenger receptors.")
AnnotationAssertion(rdfs:label obo:CL_0000880 "choroid-plexus macrophage")
EquivalentClasses(obo:CL_0000880 ObjectIntersectionOf(obo:CL_0000878 ObjectSomeValuesFrom(obo:RO_0001025 obo:UBERON_0001886) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0005044)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000880 obo:CL_0000878)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:ana") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMID:9550136") Annotation(oboInOwl:hasDbXref "PMID:37232741") obo:IAO_0000115 obo:CL_0000880 "A central nervous system macrophage found at the interface between the blood and the cerebrospinal fluid in the brain. This central nervous system macrophage expresses scavenger receptors, and has a star-like shaped body.")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:37232741") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasExactSynonym obo:CL_0000880 "cpMΦ")
AnnotationAssertion(rdfs:label obo:CL_0000880 "choroid plexus macrophage")
EquivalentClasses(obo:CL_0000880 ObjectIntersectionOf(obo:CL_4042001 ObjectSomeValuesFrom(obo:RO_0001025 obo:UBERON_0001886) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0005044)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000880 obo:CL_4042001)

# Class: obo:CL_0000881 (perivascular macrophage)

AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMID:16507898") obo:IAO_0000115 obo:CL_0000881 "A central nervous system macrophage found in small blood vessels in the brain. Markers include CD14+CD16+CD163+.")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMID:16507898") Annotation(oboInOwl:hasDbXref "PMID:37232741") obo:IAO_0000115 obo:CL_0000881 "
A central nervous system macrophage that is part of small blood vessels in the brain. Markers include CD14, CD16, CD163. In homeostatic conditions, this central nervous system macrophage has a Non-motile cell body with extending and retracting projections through the blood vessel wall.")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:37232741") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasExactSynonym obo:CL_0000881 "pvMΦ")
AnnotationAssertion(rdfs:comment obo:CL_0000881 "Markers: Human/monkey, mice: CD163. Human: CD14+CD16+CD163+.")
AnnotationAssertion(rdfs:label obo:CL_0000881 "perivascular macrophage")
EquivalentClasses(obo:CL_0000881 ObjectIntersectionOf(obo:CL_0000878 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001981) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001483) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001889) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001925)))
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000881 obo:CL_0000878)
EquivalentClasses(obo:CL_0000881 ObjectIntersectionOf(obo:CL_4042001 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001981) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001483) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001889) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001925)))
SubClassOf(obo:CL_0000881 obo:CL_4033054)
SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000881 obo:CL_4042001)

# Class: obo:CL_0000882 (thymic medullary macrophage)

Expand Down Expand Up @@ -31920,6 +31930,51 @@ AnnotationAssertion(rdfs:label obo:CL_4040005 "mesenchymal stem cell of apical p
SubClassOf(obo:CL_4040005 obo:CL_0000134)
SubClassOf(obo:CL_4040005 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0003677))

# Class: obo:CL_4042001 (border associated macrophage)

AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:37232741") Annotation(oboInOwl:hasDbXref "PMID:37626977") obo:IAO_0000115 obo:CL_4042001 "A central nervous system macrophage that is part of the choroid plexus, meningeal and perivascular spaces. A border associated macrophage interacts with various components of the CNS vasculature and meninges, it participates in immune surveillance and in the regulation of the blood brain barrier.")
AnnotationAssertion(<http://purl.org/dc/terms/contributor> obo:CL_4042001 <https://orcid.org/0000-0002-0098-8958>)
AnnotationAssertion(<http://purl.org/dc/terms/date> obo:CL_4042001 "2024-03-06T16:27:35Z"^^xsd:dateTime)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:36945367") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasExactSynonym obo:CL_4042001 "BAM")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:33556248") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasExactSynonym obo:CL_4042001 "CAM")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:37232741") oboInOwl:hasExactSynonym obo:CL_4042001 "CNS-associated macrophage")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:29426702") Annotation(oboInOwl:hasDbXref "PMID:37232741") rdfs:comment obo:CL_4042001 "A border associate macrophage expresses CD45 and CD11B. This cell is also known to have the following molecular signature: CD206, CD38, LYVE1, CD163, CD169")
AnnotationAssertion(rdfs:label obo:CL_4042001 "border associated macrophage"@en)
EquivalentClasses(obo:CL_4042001 ObjectIntersectionOf(obo:CL_0000878 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001886) ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001981) ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002360) ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002363) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0006955)))
SubClassOf(obo:CL_4042001 obo:CL_0000878)

# Class: obo:CL_4042002 (stromal choroid plexus macrophage)

AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:38347231") obo:IAO_0000115 obo:CL_4042002 "A choroid plexus macrophage that is part of the choroid plexus stroma.")
AnnotationAssertion(<http://purl.org/dc/terms/contributor> obo:CL_4042002 <https://orcid.org/0000-0002-0098-8958>)
AnnotationAssertion(<http://purl.org/dc/terms/date> obo:CL_4042002 "2024-03-06T18:53:05Z"^^xsd:dateTime)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:38347231") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasExactSynonym obo:CL_4042002 "stromal cpMΦ")
AnnotationAssertion(rdfs:label obo:CL_4042002 "stromal choroid plexus macrophage"@en)
EquivalentClasses(obo:CL_4042002 ObjectIntersectionOf(obo:CL_0000880 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0005206)))
SubClassOf(obo:CL_4042002 obo:CL_0000880)

# Class: obo:CL_4042003 (choroid epiplexus macrophage)

AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:31061494") Annotation(oboInOwl:hasDbXref "PMID:37232741") obo:IAO_0000115 obo:CL_4042003 "A choroid plexus macrophage that is part of the apical surface of the choroid plexus epithelium. This macrophage has a star-like shaped body.")
AnnotationAssertion(<http://purl.org/dc/terms/contributor> obo:CL_4042003 <https://orcid.org/0000-0002-0098-8958>)
AnnotationAssertion(<http://purl.org/dc/terms/date> obo:CL_4042003 "2024-03-06T18:53:24Z"^^xsd:dateTime)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:31433571") oboInOwl:hasExactSynonym obo:CL_4042003 "Kolmer’s cell")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:38347231") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasExactSynonym obo:CL_4042003 "cpepiMΦ")
AnnotationAssertion(Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasExactSynonym obo:CL_4042003 "epiplexus cpMΦ")
AnnotationAssertion(rdfs:label obo:CL_4042003 "choroid epiplexus macrophage"@en)
EquivalentClasses(obo:CL_4042003 ObjectIntersectionOf(obo:CL_0000880 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0003911)))
SubClassOf(obo:CL_4042003 obo:CL_0000880)

# Class: obo:CL_4042004 (dural macrophage)

AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:31061494") obo:IAO_0000115 obo:CL_4042004 "A central nervous system macrophage that is part of the dura matter. This macrophage phagocytoses intruding pathogens and foreign molecules detected in the bloodstream or in the cerebrospinal fluid. This cell has an amoeboid body with dynamic protrusions in homeostasis.")
AnnotationAssertion(<http://purl.org/dc/terms/contributor> obo:CL_4042004 <https://orcid.org/0000-0002-0098-8958>)
AnnotationAssertion(<http://purl.org/dc/terms/date> obo:CL_4042004 "2024-03-07T11:09:00Z"^^xsd:dateTime)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:37232741") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasExactSynonym obo:CL_4042004 "dmMΦ")
AnnotationAssertion(rdfs:label obo:CL_4042004 "dural macrophage"@en)
EquivalentClasses(obo:CL_4042004 ObjectIntersectionOf(obo:CL_4042001 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002363) ObjectSomeValuesFrom(obo:RO_0000053 obo:CL_0000732)))
SubClassOf(obo:CL_4042004 obo:CL_4042001)

# Class: obo:CP_0000000 (obsolete CP:0000000)

AnnotationAssertion(obo:IAO_0100001 obo:CP_0000000 obo:CL_0017500)
Expand Down

0 comments on commit 5457dfc

Please sign in to comment.