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NTR liver resident NK cells (#2472)
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* NTR liver resident NK cells
* equivalent class axiom added liver-resident NK cell
* synonyms added
* Some tweaks to def based on review (added as ref)
* Tweaks to taxon restriction to ensure passing tests

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Co-authored-by: David Osumi-Sutherland <[email protected]>
Co-authored-by: Alida Avola <[email protected]>
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@JABelfiore @dosumis @AvolaAmg
3 people authored Sep 27, 2024
1 parent 3589fcf commit b60dc2e
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19 changes: 19 additions & 0 deletions src/ontology/cl-edit.owl
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Expand Up @@ -3079,6 +3079,7 @@ Declaration(Class(obo:CL_4047018))
Declaration(Class(obo:CL_4047019))
Declaration(Class(obo:CL_4047051))
Declaration(Class(obo:CL_4047052))
Declaration(Class(obo:CL_4047101))
Declaration(Class(obo:CL_4052001))
Declaration(Class(obo:CL_4052002))
Declaration(Class(obo:CL_4052003))
Expand Down Expand Up @@ -32577,6 +32578,24 @@ AnnotationAssertion(terms:date obo:CL_4047052 "2024-07-25T13:21:19Z"^^xsd:dateTi
AnnotationAssertion(rdfs:label obo:CL_4047052 "BEST4+ colonocyte")
EquivalentClasses(obo:CL_4047052 ObjectIntersectionOf(obo:CL_1000347 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_Q8NFU0)))

# Class: obo:CL_4047101 (liver-resident natural killer cell)

AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:26330348") Annotation(oboInOwl:hasDbXref "PMID:26639736") Annotation(oboInOwl:hasDbXref "PMID:27798170") Annotation(oboInOwl:hasDbXref "PMID:32351704") Annotation(oboInOwl:hasDbXref "PMID:34230995") Annotation(oboInOwl:hasDbXref "PMID:35865550") Annotation(oboInOwl:hasDbXref "PMID:31114585") obo:IAO_0000115 obo:CL_4047101 "A natural killer cell resident to the liver, located in the hepatic sinusoids. In humans this cell type is distinguished from circulating natural killer cells by CD49a or CD69 gene expression. Liver-resident natural killer cells have also been shown to express CCR5, EOMES, KLRB1, GZMK, and CXCR6 in humans.")
AnnotationAssertion(terms:contributor obo:CL_4047101 <https://orcid.org/0009-0005-7919-4905>)
AnnotationAssertion(terms:contributor obo:CL_4047101 "https://orcid.org/0000-0001-8134-3037")
AnnotationAssertion(terms:date obo:CL_4047101 "2024-07-29T13:43:11Z"^^xsd:dateTime)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:31114585") oboInOwl:hasExactSynonym obo:CL_4047101 "he-NK")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.3389/fimmu.2019.00946") oboInOwl:hasExactSynonym obo:CL_4047101 "hepatic NK")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.3389/fimmu.2019.00946") oboInOwl:hasExactSynonym obo:CL_4047101 "hepatic natural killer cells")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:33828559") oboInOwl:hasExactSynonym obo:CL_4047101 "intrahepatic NK")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:26639736") oboInOwl:hasExactSynonym obo:CL_4047101 "liver NK cell")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:26330348") oboInOwl:hasExactSynonym obo:CL_4047101 "liver resident natural killer cell")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4047101 "liver-specific natural killer cell")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:35726345") oboInOwl:hasExactSynonym obo:CL_4047101 "lr-NK")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:34230995") rdfs:comment obo:CL_4047101 "Liver-resident natural killer cells play a crucial role in modulating the immune response during inflammation by balancing cytotoxic activity and cytokine production, thereby contributing to the maintenance of liver homeostasis and protection against excessive tissue damage.")
AnnotationAssertion(rdfs:label obo:CL_4047101 "liver-resident natural killer cell")
EquivalentClasses(obo:CL_4047101 ObjectIntersectionOf(obo:CL_0000623 ObjectSomeValuesFrom(obo:RO_0001025 obo:UBERON_0001281)))

# Class: obo:CL_4052001 (multiciliated ependymal cell)

AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25045600") Annotation(oboInOwl:hasDbXref "PMID:28067220") Annotation(oboInOwl:hasDbXref "PMID:37008045") obo:IAO_0000115 obo:CL_4052001 "An ependymal cell that lines the lateral, third, and fourth ventricles of the brain. The cell is characterized by multiple motile cilia on its apical surface, which beats in a coordinated manner to facilitate the movement of cerebrospinal fluid (CSF), contributing to brain homeostasis.")
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4 changes: 2 additions & 2 deletions src/ontology/components/hra_subset.owl
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Expand Up @@ -3694,7 +3694,7 @@
<!-- http://purl.obolibrary.org/obo/CL_2000054 -->

<owl:Class rdf:about="http://purl.obolibrary.org/obo/CL_2000054">
<obo:RO_0002175 rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_9606"/>
<obo:RO_0002175 rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_10066"/>
<oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas"/>
</owl:Class>

Expand Down Expand Up @@ -4502,5 +4502,5 @@



<!-- Generated by the OWL API (version 4.5.29) https://github.com/owlcs/owlapi -->
<!-- Generated by the OWL API (version 4.5.26.2023-07-17T20:34:13Z) https://github.com/owlcs/owlapi -->

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