Adding directional causally upstream of relations, fixes #124

Diff:

```
gitowl
gitowl ||  Diffing:  src/ontology/ro-edit.owl
gitowl ||
gitowl ||  subject: http://purl.obolibrary.org/obo/RO_0002212
gitowl ++  SubObjectPropertyOf(obo:RO_0002212 obo:RO_0002305)
gitowl ||      negatively regulates SubPropertyOf causally upstream of, negative effect
gitowl ||
gitowl ||  subject: http://purl.obolibrary.org/obo/RO_0002213
gitowl ++  SubObjectPropertyOf(obo:RO_0002213 obo:RO_0002304)
gitowl ||      positively regulates SubPropertyOf causally upstream of, positive effect
gitowl ||
gitowl ||  subject: http://purl.obolibrary.org/obo/RO_0002304
gitowl ++  Declaration(ObjectProperty(obo:RO_0002304))
gitowl ||      ObjectProperty: causally upstream of, positive effect
gitowl ++  AnnotationAssertion(dc:creator obo:RO_0002304 "cjm"^^xsd:string)
gitowl ||      <http://purl.obolibrary.org/obo/RO_0002304> creator "cjm"^^string
gitowl ++  AnnotationAssertion(rdfs:label obo:RO_0002304 "causally upstream of, positive effect")
gitowl ||      <http://purl.obolibrary.org/obo/RO_0002304> label "causally upstream of, positive effect"
gitowl ++  SubObjectPropertyOf(obo:RO_0002304 obo:RO_0002411)
gitowl ||      causally upstream of, positive effect SubPropertyOf causally upstream of
gitowl ++  AnnotationAssertion(rdfs:comment obo:RO_0002304 "holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency,
gitowl ||      <http://purl.obolibrary.org/obo/RO_0002304> comment "holds between x and y if and only if x is causally upstream of y and the progression of x increases the fre
gitowl ||
gitowl ||  subject: http://purl.obolibrary.org/obo/RO_0002305
gitowl ++  AnnotationAssertion(dc:creator obo:RO_0002305 "cjm"^^xsd:string)
gitowl ||      <http://purl.obolibrary.org/obo/RO_0002305> creator "cjm"^^string
gitowl ++  SubObjectPropertyOf(obo:RO_0002305 obo:RO_0002411)
gitowl ||      causally upstream of, negative effect SubPropertyOf causally upstream of
gitowl ++  AnnotationAssertion(rdfs:comment obo:RO_0002305 "holds between x and y if and only if x is causally upstream of y and the progression of x decreases the frequency,
gitowl ||      <http://purl.obolibrary.org/obo/RO_0002305> comment "holds between x and y if and only if x is causally upstream of y and the progression of x decreases the fre
gitowl ++  AnnotationAssertion(rdfs:label obo:RO_0002305 "causally upstream of, negative effect")
gitowl ||      <http://purl.obolibrary.org/obo/RO_0002305> label "causally upstream of, negative effect"
gitowl ++  Declaration(ObjectProperty(obo:RO_0002305))
gitowl ||      ObjectProperty: causally upstream of, negative effect
gitowl
```

src/ontology/ro-edit.owl

@@ -2336,6 +2336,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.</obo:I
 
     <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002212">
         <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
+        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002305"/>
         <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002335"/>
         <owl:propertyChainAxiom rdf:parseType="Collection">
             <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002230"/>
@@ -2355,6 +2356,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.</obo:I
 
     <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002213">
         <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
+        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002304"/>
         <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002336"/>
         <owl:propertyChainAxiom rdf:parseType="Collection">
             <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002212"/>
@@ -3222,6 +3224,28 @@ where
 
 
 
+    <!-- http://purl.obolibrary.org/obo/RO_0002304 -->
+
+    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002304">
+        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
+        <dc:creator rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</dc:creator>
+        <rdfs:comment>holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y</rdfs:comment>
+        <rdfs:label>causally upstream of, positive effect</rdfs:label>
+    </owl:ObjectProperty>
+
+
+
+    <!-- http://purl.obolibrary.org/obo/RO_0002305 -->
+
+    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002305">
+        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
+        <dc:creator rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</dc:creator>
+        <rdfs:comment>holds between x and y if and only if x is causally upstream of y and the progression of x decreases the frequency, rate or extent of y</rdfs:comment>
+        <rdfs:label>causally upstream of, negative effect</rdfs:label>
+    </owl:ObjectProperty>
+
+
+
     <!-- http://purl.obolibrary.org/obo/RO_0002312 -->
 
     <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002312">
@@ -7469,8 +7493,8 @@ Environments include natural environments or exposures, experimentally applied c
     </rdf:Description>
     <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002222">
         <obo:IAO_0000232>Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends.</obo:IAO_0000232>
-        <dc:source rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit?pli=1</dc:source>
         <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
+        <dc:source rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit?pli=1</dc:source>
         <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
     </rdf:Description>
     <rdf:Description rdf:about="http://www.w3.org/2000/01/rdf-schema#isDefinedBy">