Bug: AUC start 0 (which also needs Feature: C0 imputation)

[Gero1999]

Issue

Closes #2 #60

Description

After running NCA, AUC calculations always consider the discrete start (start at where first concentration sample was collected). This can indeed alter slightly the real values of the AUC. This is a consequence of 2 problems:

1. Doses times are being considered at the first measure, instead of at the real dose time
2. No imputed measure at dose time is consdiered

Change description.

Definition of Done

C0 imputation option for the user specified in Setup > Data Selection

How to test

• At "NCA">"NCA Results", when C0 is imputed it is expected that start=AFRLT-ARRLT (being AFRLT-ARRLT= 0 in DOSNO=1)
• At "NCA">"NCA Results", when C0 is not imputed it is expected that start={time of 1st observation}
• AUC values (auclast, aucinf...) from start=AFRLT-ARRLT are calculated when C0 is imputed
• All variables that should only be based on observed data (cmax, tmax...) are not considering C0 imputations
• Test that PKNCA also deals well with predoses as duplicates

Contributor checklist

• Code passes lintr checks
• Code passes all unit tests
• New logic covered by unit tests
• New logic is documented

Notes to reviewer

Anything that the reviewer should know before tacking the pull request?

[Gero1999]

Detected a bug in pk.nca() when using ADOSEDUR = 0 in the dataset. I will work on it

[js3110]

@Gero1999 I am getting a new error now when I run the IV Bolus data:

Warning: Values from `exclude` are not uniquely identified; output will contain list-cols.
• Use `values_fn = list` to suppress this warning.
• Use `values_fn = {summary_fun}` to summarise duplicates.
• Use the following dplyr code to identify duplicates.
  {data} |>
  dplyr::summarise(n = dplyr::n(), .by = c(STUDYID, PCSPEC, ANALYTE, USUBJID, DOSNO,
  PPTESTCD)) |>
  dplyr::filter(n > 1L)
Warning: Error in filter: ℹ In argument: `TIME >= (lambda.z.time.first + start) |
  is.na(lambda.z.time.first)`.
ℹ In group 1: `STUDYID = "XX01"`, `PCSPEC = "SERUM"`, `ANALYTE = "Analyte01"`,
  `USUBJID = 11101`, `DOSNO = 1`.
Caused by error in `lambda.z.time.first + start`: