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I would like to perform protein differential expression analysis on matched samples comparing two conditions. Similar to your vignette ( below ), only prot. ADT has been CLR ( marg=2 ) normalized. Data integrated on RNA alone.
Hello,
I would like to perform protein differential expression analysis on matched samples comparing two conditions. Similar to your vignette ( below ), only prot. ADT has been CLR ( marg=2 ) normalized. Data integrated on RNA alone.
https://satijalab.org/seurat/articles/de_vignette#:~:text=The%20bulk%20of%20Seurat's%20differential,of%20cells%2C%20specify%20the%20ident.
Can you please advise a suitable approach for this? Could pseudo bulk be employed or FindMarkers()?
Thanks, appreciate your work!
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