Spike-to-Fluroscence model of jGCaMP8 sensors

author: Ziqiang Wei

email: weiz (at) janelia (dot) hhmi (dot) org

Introduction

This repo includes the codes for a variety of spike-to-fluroscence models and fluroscence-to-spike models that were used to evaluate the performance of newly developed jGCaMP8 sensors.

Figure 5a

check Example_S2F_dFF_fits.ipynb (Figure A)

Figure 5b

check Example_S2F_dFF_fits.ipynb (Figure D)

Figure 5c

check Explained_variance_fits.ipynb (Figure C)

Extended Data Fig. 18

check Fitting_para_statistics.ipynb

Fits

Please contact with Ziqiang Wei with model fits. These include models:

1. Linear Spike-to-Fluroscence model
2. Nonlinear Spike-to-Fluroscence model
3. CFOOSPI Fluroscence-to-Spike model
4. MLSpike Fluroscence-to-Spike model

Also these include simultaneous data of indicators:

1. jGCaMP8f/m/s
2. jGCaMP7f
3. jGCaMP6f/s
4. jGCaMP6-TG f/s
5. XCaMP

Citations

Citation of S2F or F2S model (or for the usage of the model)

Wei, Z., Lin, B. J., Chen, T. W., Daie, K., Svoboda, K., & Druckmann, S. (2020). A comparison of neuronal population dynamics measured with calcium imaging and electrophysiology. PLoS computational biology, 16(9), e1008198.

Citation of simultaneous spiking-imaging data

Zhang, Y., Rózsa, M., Liang, Y., Bushey, D., Wei, Z., Zheng, J., ... & Looger, L. L. (2023). Fast and sensitive GCaMP calcium indicators for imaging neural populations. Nature, 1-8.