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Preeclampsia Early Assessment of Risk from Liquid Biopsy (PEARL)

This repository contains code for the study:
Mohamed Adil, Teodora R. Kolarova, Anna-Lisa Doebley, Leah A. Chen, Cara Tobey, Patricia Galipeau, Sam Rosen, Michael Yang, Brice Colbert, Robert D. Patton, Thomas W. Persse, Erin Kawelo, Jonathan B. Reichel, Colin C. Pritchard, Shreeram Akilesh, Christina M. Lockwood, Gavin Ha†, Raj Shree†. Preeclampsia risk prediction from non-invasive prenatal cell-free DNA screening. Under Review.

System requirements

Dependencies

Python/3.9.6-GCCcore-11.2.0

Package Version
Jupyterlab 3.1.6
Joblib 1.0.1
Matplotlib 3.7.1
Pandas 2.0.2
scikit-learn 1.1.1
scipy 1.12.0
seaborn 0.11.2
sklearn 0.0.post1
xgboost 1.6.1

Input files

Meta data - Supplementary_Tables.xlsx
Features data - Raw_feature_tables.xlsx

Installation guide

Load jupyter notebook in jupyterlab

Demo/ Instructions for use

Update path to meta and feature data.
Update path for output files.
Run > Run All Cells

Expected Outputs

Trained Griffin-FF model
Trained Griffin-PE models
Figure 2G & 2H

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