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Mathematical model to estimate mutation origination and fixation dependent on somatic cancer genotypes

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Requirements

A local installation of python is required.

If you would like to generate results for the mutation rates you also require R and the libcurl4-openssl-dev library.

Instructions

Dependencies

To install all python dependencies run:

cd code
./setup.sh

We provide the mutation rate results obtained from cancereffectsizeR, but if you want to generate those results run:

Rscript ./ces_installation.R

Generating results and figures

If you want to generate the mutation rates for each of the four genes (they can also be imported directly in python), run:

Rscript ./generate_mutation_rates.R

The main method to produce all the results is:

python main.py

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