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Merge pull request #3512 from broadinstitute/hail-search-shared-tests
shared utilities for hail backend tests
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@@ -0,0 +1,54 @@ | ||
from copy import deepcopy | ||
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FAMILY_3_SAMPLE = { | ||
'sample_id': 'NA20870', 'individual_guid': 'I000007_na20870', 'family_guid': 'F000003_3', | ||
'project_guid': 'R0001_1kg', 'affected': 'A', 'sex': 'M', | ||
} | ||
EXPECTED_SAMPLE_DATA = { | ||
'VARIANTS': [ | ||
{'sample_id': 'HG00731', 'individual_guid': 'I000004_hg00731', 'family_guid': 'F000002_2', 'project_guid': 'R0001_1kg', 'affected': 'A', 'sex': 'F'}, | ||
{'sample_id': 'HG00732', 'individual_guid': 'I000005_hg00732', 'family_guid': 'F000002_2', 'project_guid': 'R0001_1kg', 'affected': 'N', 'sex': 'M'}, | ||
{'sample_id': 'HG00733', 'individual_guid': 'I000006_hg00733', 'family_guid': 'F000002_2', 'project_guid': 'R0001_1kg', 'affected': 'N', 'sex': 'F'}, | ||
FAMILY_3_SAMPLE, | ||
], 'SV_WES': [ | ||
{'sample_id': 'HG00731', 'individual_guid': 'I000004_hg00731', 'family_guid': 'F000002_2', 'project_guid': 'R0001_1kg', 'affected': 'A', 'sex': 'F'}, | ||
{'sample_id': 'HG00732', 'individual_guid': 'I000005_hg00732', 'family_guid': 'F000002_2', 'project_guid': 'R0001_1kg', 'affected': 'N', 'sex': 'M'}, | ||
{'sample_id': 'HG00733', 'individual_guid': 'I000006_hg00733', 'family_guid': 'F000002_2', 'project_guid': 'R0001_1kg', 'affected': 'N', 'sex': 'F'} | ||
], | ||
} | ||
CUSTOM_AFFECTED_SAMPLE_DATA = {'VARIANTS': deepcopy(EXPECTED_SAMPLE_DATA['VARIANTS'])} | ||
CUSTOM_AFFECTED_SAMPLE_DATA['VARIANTS'][0]['affected'] = 'N' | ||
CUSTOM_AFFECTED_SAMPLE_DATA['VARIANTS'][1]['affected'] = 'A' | ||
CUSTOM_AFFECTED_SAMPLE_DATA['VARIANTS'][2]['affected'] = 'U' | ||
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FAMILY_1_SAMPLE_DATA = { | ||
'VARIANTS': [ | ||
{'sample_id': 'NA19675', 'individual_guid': 'I000001_na19675', 'family_guid': 'F000001_1', 'project_guid': 'R0001_1kg', 'affected': 'A', 'sex': 'M'}, | ||
{'sample_id': 'NA19678', 'individual_guid': 'I000002_na19678', 'family_guid': 'F000001_1', 'project_guid': 'R0001_1kg', 'affected': 'N', 'sex': 'M'}, | ||
], | ||
} | ||
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ALL_AFFECTED_SAMPLE_DATA = deepcopy(EXPECTED_SAMPLE_DATA) | ||
ALL_AFFECTED_SAMPLE_DATA['MITO'] = [ | ||
{'sample_id': 'HG00733', 'individual_guid': 'I000006_hg00733', 'family_guid': 'F000002_2', 'project_guid': 'R0001_1kg', 'affected': 'N', 'sex': 'F'}, | ||
] | ||
FAMILY_5_SAMPLE = { | ||
'sample_id': 'NA20874', 'individual_guid': 'I000009_na20874', 'family_guid': 'F000005_5', 'project_guid': 'R0001_1kg', 'affected': 'N', 'sex': 'M', | ||
} | ||
ALL_AFFECTED_SAMPLE_DATA['VARIANTS'].append(FAMILY_5_SAMPLE) | ||
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def get_hail_search_body(genome_version='GRCh38', num_results=100, sample_data=None, omit_sample_type=None, **search_body): | ||
sample_data = sample_data or EXPECTED_SAMPLE_DATA | ||
if omit_sample_type: | ||
sample_data = {k: v for k, v in sample_data.items() if k != omit_sample_type} | ||
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search = { | ||
'sample_data': sample_data, | ||
'genome_version': genome_version, | ||
'num_results': num_results, | ||
**search_body, | ||
} | ||
search.update(search_body or {}) | ||
return search |
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@@ -10,46 +10,11 @@ | |
get_variants_for_variant_ids, InvalidSearchException | ||
from seqr.utils.search.search_utils_tests import SearchTestHelper, MOCK_COUNTS | ||
from seqr.views.utils.test_utils import PARSED_VARIANTS | ||
from hail_search.test_utils import get_hail_search_body, EXPECTED_SAMPLE_DATA, FAMILY_1_SAMPLE_DATA, FAMILY_3_SAMPLE, \ | ||
ALL_AFFECTED_SAMPLE_DATA, CUSTOM_AFFECTED_SAMPLE_DATA | ||
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MOCK_HOST = 'http://test-hail-host' | ||
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FAMILY_3_SAMPLE = { | ||
'sample_id': 'NA20870', 'individual_guid': 'I000007_na20870', 'family_guid': 'F000003_3', | ||
'project_guid': 'R0001_1kg', 'affected': 'A', 'sex': 'M', | ||
} | ||
EXPECTED_SAMPLE_DATA = { | ||
'VARIANTS': [ | ||
{'sample_id': 'HG00731', 'individual_guid': 'I000004_hg00731', 'family_guid': 'F000002_2', 'project_guid': 'R0001_1kg', 'affected': 'A', 'sex': 'F'}, | ||
{'sample_id': 'HG00732', 'individual_guid': 'I000005_hg00732', 'family_guid': 'F000002_2', 'project_guid': 'R0001_1kg', 'affected': 'N', 'sex': 'M'}, | ||
{'sample_id': 'HG00733', 'individual_guid': 'I000006_hg00733', 'family_guid': 'F000002_2', 'project_guid': 'R0001_1kg', 'affected': 'N', 'sex': 'F'}, | ||
FAMILY_3_SAMPLE, | ||
], 'SV_WES': [ | ||
{'sample_id': 'HG00731', 'individual_guid': 'I000004_hg00731', 'family_guid': 'F000002_2', 'project_guid': 'R0001_1kg', 'affected': 'A', 'sex': 'F'}, | ||
{'sample_id': 'HG00732', 'individual_guid': 'I000005_hg00732', 'family_guid': 'F000002_2', 'project_guid': 'R0001_1kg', 'affected': 'N', 'sex': 'M'}, | ||
{'sample_id': 'HG00733', 'individual_guid': 'I000006_hg00733', 'family_guid': 'F000002_2', 'project_guid': 'R0001_1kg', 'affected': 'N', 'sex': 'F'} | ||
], | ||
} | ||
CUSTOM_AFFECTED_SAMPLE_DATA = {'VARIANTS': deepcopy(EXPECTED_SAMPLE_DATA['VARIANTS'])} | ||
CUSTOM_AFFECTED_SAMPLE_DATA['VARIANTS'][0]['affected'] = 'N' | ||
CUSTOM_AFFECTED_SAMPLE_DATA['VARIANTS'][1]['affected'] = 'A' | ||
CUSTOM_AFFECTED_SAMPLE_DATA['VARIANTS'][2]['affected'] = 'U' | ||
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FAMILY_1_SAMPLE_DATA = { | ||
'VARIANTS': [ | ||
{'sample_id': 'NA19675', 'individual_guid': 'I000001_na19675', 'family_guid': 'F000001_1', 'project_guid': 'R0001_1kg', 'affected': 'A', 'sex': 'M'}, | ||
{'sample_id': 'NA19678', 'individual_guid': 'I000002_na19678', 'family_guid': 'F000001_1', 'project_guid': 'R0001_1kg', 'affected': 'N', 'sex': 'M'}, | ||
], | ||
} | ||
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ALL_AFFECTED_SAMPLE_DATA = deepcopy(EXPECTED_SAMPLE_DATA) | ||
ALL_AFFECTED_SAMPLE_DATA['MITO'] = [ | ||
{'sample_id': 'HG00733', 'individual_guid': 'I000006_hg00733', 'family_guid': 'F000002_2', 'project_guid': 'R0001_1kg', 'affected': 'N', 'sex': 'F'}, | ||
] | ||
FAMILY_5_SAMPLE = { | ||
'sample_id': 'NA20874', 'individual_guid': 'I000009_na20874', 'family_guid': 'F000005_5', 'project_guid': 'R0001_1kg', 'affected': 'N', 'sex': 'M', | ||
} | ||
ALL_AFFECTED_SAMPLE_DATA['VARIANTS'].append(FAMILY_5_SAMPLE) | ||
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@mock.patch('seqr.utils.search.hail_search_utils.HAIL_BACKEND_SERVICE_HOSTNAME', MOCK_HOST) | ||
class HailSearchUtilsTests(SearchTestHelper, TestCase): | ||
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@@ -62,17 +27,8 @@ def setUp(self): | |
'results': PARSED_VARIANTS, 'total': 5, | ||
}) | ||
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def _test_minimal_search_call(self, search_body, num_results=100, sample_data=None, omit_sample_type=None): | ||
sample_data = sample_data or EXPECTED_SAMPLE_DATA | ||
if omit_sample_type: | ||
sample_data = {k: v for k, v in sample_data.items() if k != omit_sample_type} | ||
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expected_search = { | ||
'sample_data': sample_data, | ||
'genome_version': 'GRCh37', | ||
'num_results': num_results, | ||
} | ||
expected_search.update(search_body) | ||
def _test_minimal_search_call(self, **kwargs): | ||
expected_search = get_hail_search_body(genome_version='GRCh37', **kwargs) | ||
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executed_request = responses.calls[-1].request | ||
self.assertEqual(executed_request.headers.get('From'), '[email protected]') | ||
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@@ -101,7 +57,7 @@ def _test_expected_search_call(self, search_fields=None, gene_ids=None, interval | |
} | ||
expected_search.update({field: self.search_model.search[field] for field in search_fields or []}) | ||
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self._test_minimal_search_call(expected_search, **kwargs) | ||
self._test_minimal_search_call(**expected_search, **kwargs) | ||
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@responses.activate | ||
def test_query_variants(self): | ||
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@@ -217,14 +173,14 @@ def test_get_variant_query_gene_counts(self): | |
def test_get_single_variant(self): | ||
variant = get_single_variant(self.families, '2-103343353-GAGA-G', user=self.user) | ||
self.assertDictEqual(variant, PARSED_VARIANTS[0]) | ||
self._test_minimal_search_call({ | ||
'variant_ids': [['2', 103343353, 'GAGA', 'G']], 'variant_keys': [], | ||
}, num_results=1, sample_data=ALL_AFFECTED_SAMPLE_DATA, omit_sample_type='SV_WES') | ||
self._test_minimal_search_call( | ||
variant_ids=[['2', 103343353, 'GAGA', 'G']], variant_keys=[], | ||
num_results=1, sample_data=ALL_AFFECTED_SAMPLE_DATA, omit_sample_type='SV_WES') | ||
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get_single_variant(self.families, 'prefix_19107_DEL', user=self.user) | ||
self._test_minimal_search_call({ | ||
'variant_ids': [], 'variant_keys': ['prefix_19107_DEL'], | ||
}, num_results=1, sample_data=EXPECTED_SAMPLE_DATA, omit_sample_type='VARIANTS') | ||
self._test_minimal_search_call( | ||
variant_ids=[], variant_keys=['prefix_19107_DEL'], | ||
num_results=1, sample_data=EXPECTED_SAMPLE_DATA, omit_sample_type='VARIANTS') | ||
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with self.assertRaises(InvalidSearchException) as cm: | ||
get_single_variant(self.families, '2-103343353-GAGA-G', user=self.user, return_all_queried_families=True) | ||
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@@ -234,9 +190,9 @@ def test_get_single_variant(self): | |
) | ||
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get_single_variant(self.families.filter(guid='F000003_3'), '2-103343353-GAGA-G', user=self.user, return_all_queried_families=True) | ||
self._test_minimal_search_call({ | ||
'variant_ids': [['2', 103343353, 'GAGA', 'G']], 'variant_keys': [], | ||
}, num_results=1, sample_data={'VARIANTS': [FAMILY_3_SAMPLE]}) | ||
self._test_minimal_search_call( | ||
variant_ids=[['2', 103343353, 'GAGA', 'G']], variant_keys=[], | ||
num_results=1, sample_data={'VARIANTS': [FAMILY_3_SAMPLE]}) | ||
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responses.add(responses.POST, f'{MOCK_HOST}:5000/search', status=200, json={'results': [], 'total': 0}) | ||
with self.assertRaises(InvalidSearchException) as cm: | ||
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@@ -247,13 +203,13 @@ def test_get_single_variant(self): | |
def test_get_variants_for_variant_ids(self): | ||
variant_ids = ['2-103343353-GAGA-G', '1-248367227-TC-T', 'prefix-938_DEL'] | ||
get_variants_for_variant_ids(self.families, variant_ids, user=self.user) | ||
self._test_minimal_search_call({ | ||
'variant_ids': [['2', 103343353, 'GAGA', 'G'], ['1', 248367227, 'TC', 'T']], | ||
'variant_keys': ['prefix-938_DEL'], | ||
}, num_results=3, sample_data=ALL_AFFECTED_SAMPLE_DATA) | ||
self._test_minimal_search_call( | ||
variant_ids=[['2', 103343353, 'GAGA', 'G'], ['1', 248367227, 'TC', 'T']], | ||
variant_keys=['prefix-938_DEL'], | ||
num_results=3, sample_data=ALL_AFFECTED_SAMPLE_DATA) | ||
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get_variants_for_variant_ids(self.families, variant_ids, user=self.user, dataset_type='VARIANTS') | ||
self._test_minimal_search_call({ | ||
'variant_ids': [['2', 103343353, 'GAGA', 'G'], ['1', 248367227, 'TC', 'T']], | ||
'variant_keys': [], | ||
}, num_results=2, sample_data=ALL_AFFECTED_SAMPLE_DATA, omit_sample_type='SV_WES') | ||
self._test_minimal_search_call( | ||
variant_ids=[['2', 103343353, 'GAGA', 'G'], ['1', 248367227, 'TC', 'T']], | ||
variant_keys=[], | ||
num_results=2, sample_data=ALL_AFFECTED_SAMPLE_DATA, omit_sample_type='SV_WES') |