Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Hotfix for transcript projection onto haplotypes with tandem duplications in vg rna #4397

Merged
merged 1 commit into from
Sep 13, 2024

Conversation

jeizenga
Copy link
Contributor

@jeizenga jeizenga commented Sep 12, 2024

Changelog Entry

To be copied to the draft changelog by merger:

  • vg rna now excludes haplotypes with tandem duplications when projecting rather than crashing on them

Description

This is a less-than-ideal solution to the problem since it leads to loss of some haplotype-specific transcripts, but it's an improvement over the current behavior, which is to crash on a failing assert. A better solution will be to always build the R-index alongside the GBWT so that we can get reachability information from locate queries. This will require some more pipeline engineering in vg rna and vg autoindex.

@jeizenga jeizenga merged commit 4db75c2 into master Sep 13, 2024
2 checks passed
Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
None yet
Projects
None yet
Development

Successfully merging this pull request may close these issues.

2 participants