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3024929

amolin19 edited this page May 5, 2021 · 2 revisions

3024929 - Platelets [#/volume] in Blood by Automated count

Platelets are the cells that circulate within our blood and bind together when they recognize damaged blood vessels. 1

In the OMOP vocabulary 3024929 is a Standard Concept that represents the measurement Platelets [#/volume] in Blood by Automated count

The recommended low and high values for each unit associated with 3024929 are below. These are not meant to be normal values. Rather, these are meant to be biologically plausible values. For example, it would be implausible to see a patient with a weight of 0 kg though a person could be 2.5 kg.

8961

In the OMOP vocabulary 8961 is a Standard Concept that represents the unit thousand per cubic millimeter

Plausible Low Value

1

Plausible High Value

4000.0

Rationale

A normal platelet count ranges from 150,000 to 450,000 platelets per microliter of blood. Having more than 450,000 platelets is a condition called thrombocytosis; having less than 150,000 is known as thrombocytopenia. 1 Given that, for unit_concept_id 8961, we divide those values by 1000 to get a normal range of 150 to 450 per thousand cubic millimeter.
NB: A cubic millimeter is equivalent to a microliter and 450,000/microL = 450 x 109/L

Thrombocytopenia is typically diagnosed for platelet counts less that 150,000 per microliter (or 150 per thousand cubic millimeter) 2, with severe bleeding occurring at counts less than 10,000 to 20,000 per microliter (or 10 to 20 per thousand cubic millimeter). 3 This study on severe primary autoimmune thrombocytopenia in pregnancy 4, contains people with as few as 2,000 platelets per microliter (or 2, per thousand cubic millimeter).

While rare, this study on essential thrombocythemia 5, includes a person with more than 3,600,000 platelets per microliter (or, more than 3,600 per thousand cubic millimeter), thus a value of 4000 (per thousand cubic millimiter) seems like a biologically plausible upper bound.

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