Cell Modelling and Simulation

Citation: 6. Low, KKM, Ling, MHT. 2025. Cell Modelling and Simulation. In Ranganathan, S., Cannataro, M., and Khan, A. M. (eds), Encyclopedia of Bioinformatics and Computational Biology (2nd Edition) Volume 4, Pages 445-455. Oxford: Elsevier. ISBN 978-0-323-95503-4.

Link to [Abstract]

How phenotypes can be predicted from the corresponding genotypes is an important question in the post-genomic era. Whole cell mathematical model is a vital tool to aggregate knowledge of an organism. Different types of models can be developed and a computationally simulatable model, such as one built using differential equations, can be used to evaluate state of the art knowledge of an organism. A model can be based on different cellular levels, from reactions to gene regulations; or even with spatial considerations. This article will also list the current tools available for model building and simulation, before an illustration of the recent applications of whole cell modelling.