Potential De Novo Origins of Archaebacterial Glycerol 1 Phosphate Dehydrogenase (G1PDH).

Citation: Thong-Ek, C, Usman, S, Woo, JH, Chua, JW, Kwek, BZN, Ardhanari-Shanmugam, KD, B, V, Shahrukh, K, Ling, MHT. 2019. Potential De Novo Origins of Archaebacterial Glycerol-1-Phosphate Dehydrogenase (G1PDH). Acta Scientific Microbiology 2(6): 106-110.

Link to [PDF].

Here is the permanent [PDF] and [data set] link to my archive.

Eubacterial glycerol-1-phosphate dehydrogenase (G1PDH) may originate from archaebacteria by horizontal gene transfer; however, the origins of archaebacterial G1PDH remains unanswered. While recent studies show possible de novo origination of protein encoding genes and functional promoters, the mechanism of de novo origins of functional genes remains debatable. In this study, we examine the probability of de novo emergence of putative G1PDH from random sequences. Our results show that high number of open reading frames in random sequences and 71.8% of randomly generated sequences have 9.88% probability of being putative G1PDH. Hence, de novo origination archaebacterial G1PDH from random sequences is plausible.